Using a projection modeling system developed by MIT’s Joint Program on the Science and Policy of Global Change, the Integrated Global System Model (IGSM), we provide an integrated assessment of how human activities, given our current development path, are interacting with complex Earth systems and ultimately affecting the natural resources on which we depend. In the first part of the presentation (lead by Dr, Erwan Monier), we introduce the IGSM, and describe the capabilities of the modeling system to simulate the uncertainty in the future climate response to anthropogenic emissions of greenhouse gases and aerosols. In the second part of the presentation (lead by Dr, Sergey Paltsev), we provide an integrated economic and climate projection of the 21^st century--not a prediction, as the future will ultimately be determined by actions taken over the next decades that are intended to stabilize our relationship with the planet. We incorporate the emissions targets currently proposed by the international community to address the challenges of climate change.